| Saint Dragon | C64 / Amiga | Storm/The Sales Curve | 1990 | Shoot'em Up | 76% | - |
| Samurai Warrior: The Battles of Usagi Yojimbo | C64 | Firebird | 1988 | Adventure | 85% | - |
| Scarabaeus | C64 | Ariolasoft | 1985 | Adventure | 82% | - |
| Scorpion | Amiga | Digital Magic Software | 1989 | Platformer | 34% | - |
| Scramble Spirits | C64 / Amiga | Grandslam | 1990 | Shoot'em Up | 46% | - |
| SDI: Strategic Defence Initiative | C64 / Amiga | Activision | 1988 | Shoot'em Up | 71% | - |
| Sentinel | C64 | Synapse Software | 1984 | Shoot'em Up | 78% | - |
| Sequal | C64 | | | | 0% | - |
| Seymour at the Movies | C64 | Codemasters | 1992 | Platformer | 61% | - |
| Shadow of the Beast | C64 / Amiga | Psygnosis | 1989 | Platformer | 75% | - |
| Shadow Warriors | C64 / Amiga | Ocean | 1990 | Beat'em Up | 66% | - |
| Shadowgate | Amiga | Mindscape | 1987 | Adventure | 68% | - |
| Sherlock: The Riddle of the Crown Jewels | C64 / Amiga | Infocom | 1987 | Adventure | 73% | - |
| Shinobi | C64 / Amiga | Virgin Games | 1989 | Beat'em Up | 82% | - |
| Shirley Muldowney's Top Fuel Challenge | C64 | Cosmi | 1987 | Racing | 67% | - |
| Shōgun | C64 | Virgin Games | 1986 | Adventure | 82% | - |
| Sidewalk | C64 | Infogrames | 1987 | Adventure | 68% | - |
| Silent Service | C64 | MicroProse Software | 1985 | Simulation | 85% | - |
| Sim City | C64 / Amiga | Infogrames | 1989 | Strategy | 83% | - |
| Simulcra | Amiga | MicroStyle | 1990 | Shooter | 76% | - |
| Skate Crazy | C64 | Gremlin Graphics | 1988 | Sports | 64% | - |
| Skate of the Art | Amiga | Linel | 1989 | Sports | 58% | - |
| Skate or Die! | C64 | Electronic Arts | 1987 | Sports | 84% | - |
| Sky High Stuntman | C64 | Codemasters | 1991 | Shoot'em Up | 54% | - |
| Slaine | C64 | Martech | 1987 | Adventure | 55% | - |
| Slightly Magic | C64 | Codemasters | 1991 | Platformer | 58% | - |
| Smash T.V. | C64 | Ocean | 1991 | Action | 78% | - |
| Snakemania - Super Snake Simulator | C64 | Alternative Software | 1988 | Worm/Snake | 67% | - |
| Soccer Pinball | C64 | Codemasters | 1992 | Pinball | 45% | - |
| Soldier of Fortune | C64 | Firebird | 1988 | Platformer | 73% | - |
| Sonic Boom | C64 / Amiga | Activision | 1990 | Shoot'em Up | 46% | - |
| Sorceror's Apprentice | Amiga | Actual Screenshots | 1990 | Platformer | 50% | - |
| Space Ace | Amiga | ReadySoft | 1989 | Adventure | 52% | - |
| Space Gun | C64 | Ocean | 1992 | Shoot'em Up | 63% | - |
| Space Harrier | C64 / Amiga | Elite | 1989 | Shoot'em Up | 65% | - |
| Speedball 2: Brutal Deluxe | Amiga | Image Works | 1990 | Sports | 88% | - |
| Spherical | C64 / Amiga | Rainbow Arts | 1989 | Platformer | 73% | - |
| Spikey in Transylvania | C64 | Codemasters | 1991 | Adventure | 79% | - |
| Split Personalities | C64 | Domark | 1986 | Puzzle | 77% | - |
| Square Out | C64 | Terror Design | 1991 | Brain | 0% | - |
| Stack Up | C64 | Zeppelin Games | 1991 | Tetris | 40% | - |
| Star Wars: Return of the Jedi | C64 / Amiga | Domark | 1988 | Action | 56% | - |
| Star Wars: The Empire Strikes Back | C64 / Amiga | Domark | 1988 | Shoot'em Up | 66% | - |
| Starbyte Super Soccer | C64 | Starbyte Software | 1990 | Sports | 44% | - |
| Starglider | C64 | Rainbird | 1986 | Shoot'em Up | 67% | - |
| Starglider 2 | Amiga | Rainbird | 1988 | Shoot'em Up | 84% | - |
| Stock Market | Amiga | Tynesoft | 1988 | Strategy | 50% | - |
| Storm Across Europe | C64 / Amiga | Strategic Simulations, Inc. | 1990 | Strategy | 69% | - |
| Stormlord | C64 / Amiga | Hewson | 1989 | Platformer | 73% | - |
| Strangeloop | C64 | Virgin Games | 1985 | Action | 80% | - |
| Street Rod 2 | Amiga | California Dreams | 1991 | Racing | 79% | - |
| Street Sports Basketball | C64 | Epyx | 1987 | Sports | 76% | - |
| Street Sports Soccer | C64 | Epyx | 1988 | Sports | 64% | - |
| Street Surfer | C64 | Entertainment USA | 1986 | Sports | 68% | - |
| Striker Manager | Amiga | D&H Games | 1991 | Sports | 50% | - |
| Stunt Car Racer | C64 / Amiga | MicroStyle | 1989 | Racing | 86% | - |
| Stümp | C64 | CP Verlag | 1991 | Adventure | 80% | - |
| Su Sweet | C64 | CP Verlag | 1991 | Tetris | 68% | - |
| Sub Battle Simulator | C64 / Amiga | Epyx | 1987 | Simulation | 61% | - |
| Summer Games II | C64 | Epyx | 1985 | Sports | 86% | - |
| Summer Olympiad | C64 / Amiga | Tynesoft | 1988 | Sports | 75% | - |
| Super Cars | Amiga | Gremlin Graphics | 1990 | Racing | 81% | - |
| Super Cars II | Amiga | Gremlin Graphics | 1991 | Racing | 85% | - |
| Super Grand Prix | Amiga | Codemasters | 1991 | Racing | 58% | - |
| Super Hang-On | C64 / Amiga | Electric Dreams | 1988 | Racing | 76% | - |
| Super Seymour Saves the Planet | C64 | Codemasters | 1992 | Platformer | 69% | - |
| Super Sprint | C64 | Electric Dreams | 1987 | Racing | 70% | - |
| Super Trucker | C64 | CP Verlag | 1991 | Driving | 62% | - |
| Superstar Soccer | C64 | Mindscape | 1987 | Sports | 75% | - |
| Supremacy | C64 / Amiga | Melbourne House | 1990 | Strategy | 82% | - |
| SWIV - Silk Worm IV | Amiga | Storm | 1991 | Shoot'em Up | 83% | - |
| Sword of Aragon | Amiga | Strategic Simulations, Inc. | 1990 | Strategy | 69% | - |
| Swords & Galleons | Amiga | Idea Software | 1991 | Strategy | 66% | - |